What we do
In Vitro Services
Agilux offers fast turnaround in vitro ADMET studies providing our clients with reliable data within one week. The key to balancing the competing demands of data quality, speed of execution and cost is an understanding of the data and data quality requirements necessary to satisfy experimental objectives. To this end, Agilux offers a suite of standardized, fit-for-purpose non-GLP in vitro Research Grade Assays (RGAs) to address client needs across the drug discovery continuum.
We offer the following in vitro ADMET assays:
Protein Binding
- RED (Rapid Equilibrium Device)
- Ultracentrifugation
Melanin Binding
Metabolic Stability
- Liver microsomes, S9, whole blood, aqueous buffers
- Human, monkey, rodent, dog, swine and other species upon request
Plasma Stability
RBC Partitioning
Whole Blood Binding
Microsomal Binding
CYP450 Inhibition
- Fluorogenic substrates
- Drug probes with LC/MS/MS detection
- Human recombinant enzymes
- CYP1A2, 2C8, 2C9, 2C19, 2D6, 3A4
Agilux offers in vitro ADMET assays that support early research and development. Agilux brings to bear purpose built processes and procedures combined with "practical innovation" to support the fast turnaround and data quality requirements of its non-GLP in vitro discovery clients. Our scientists have leveraged their extensive industry and CRO experience to provide clients with better data faster. Each assay includes drug reference controls plus several built-in controls to ensure assay performance and assess test article behavior under assay conditions.
