In-Vivo

In Vivo (PK) PharmacokineticsAAALAC

 

 

The iterative nature of In Vivo Pharmacokinetic screening requires rapid cycle times with turn-on-a-dime changes in priorities. Agilux has built a team of experienced scientists with facilities and processes designed specifically to meet these challenging requirements. When combined with Agilux discovery bioanalysis, Agilux provides you with standard PK parameters from WinNonLin within 5 days of dosing.

 

in-vivo


Rapid In Vivo Pharmacokinetics Screening Studies

 

Agilux provides rapid In Vivo (PK) Pharmacokinetic  screening studies in rodent and non-rodent species. .Agilux is accredited by the Association for Assessment and Accreditation of Laboratory Animal Care (AAALAC) and approved by the NIH Office of Laboratory Animal Welfare (OLAW).


From standard screening to more complex studies, our team of experienced Study Directors can also assist in designing the best strategy and protocols customized to suit any drug discovery program.


Rapid study initiations (within less than one week from initial request) and standardized abbreviated IACUC protocols with fully integrated LC-MS/MS bioanalysis of PK samples result in Better Data Faster.


The Agilux In Vivo PK screening service utilizes a wide variety of dose regimens and administration routes in both rodent and non-rodent species. We have standardized designs, but our experienced PI’s can also design, conduct, and interpret the In Vivo study to meet your specific requirements. Rapid study initiation is facilitated by our maintenance of a supply of rodents and a colony of non-rodent species.


The Agilux PK team has perfected techniques that allow evaluations on small volume samples, using conventional bioanalytical procedures. For example, we frequently perform the following small volume procedures:

 

 

For more detailed information on our In Vivo services, please see the details below and contact us at info@agiluxlabs.com.

 

View the In Vivo Product Specification

 

in-vivo

  • Single agents, cassette dosing, single dose, repeat dose
  • Dosing by PO, IV, IP, SC, etc. route
  •  Serial sampling in all species
  • Tissue, urine and CSF collection
  • Bile collections by bile duct cannulation (BDC)
  • Fully integrated In Vivo / bioanalysis service or biological samples shipped back to sponsor

 

 

 

 

 

in-vivo

  • Rank Ordering Compounds/Formulations
  • Bioavailability and Bioequivalence
  • Dose Proportionality (ascending dose)
  • Dose Linearity (multiple dose)
  • Drug-Drug Interactions
  • Special Populations
  • Tissue Distribution  ( non radioactive)
  • Blood Brain Barrier
  • Pharmacokinetics (non-compartmental)

 

 

 

 

in-vivo

 

  • Standardized quotes and pricing matrices- quotes within 24 hours
  • Activity based IACUC approval
  • One page protocols
  • Flexible scheduling to allow last-minute changes to study protocol
  • Standing colony of animals- Study starts within a week of a signed quote
  • Fully integrated In Vivo and bioanalysis – PK data within 3-5 days of dosing

 

 

 

 

 

 

  • Biological samples (shipped for analysis at your lab of choice)
  • Standard Agilux Discovery Report (when bioanalysis performed at Agilux)
    • Sample concentration
    • PK parameters (using WinNonlin)